Submitted:

Eric A Murphy, Wolgang Wrasidio, Konstantin Stoletov, Elena Dneprovskaia, Michel McElroy, Jeff Lingquist, Adrian Sasaldanha, Richard Soll, George E. Davis, Michael Bouvet, Richard Klemke, and David A. Cheresh. Allosteric RAAF Kinase Inhibitor Disrupts Angiogenesis by Preventing Endothelial Lumen Formation. JCI. Submitted.

Jill M. Ricono, Milan. Makale, Yingchun Wang, L. Barnes, DAvid Schlaepfer, Richard Klemke, David Cheresh. EGFR REgulates Metastasis through an Integrin αvβ5/src Signaling Axis. 2007. Submitted.

Konstantin Stoletov, Karsten Hartvigsen, Lotte F. Hansen, Joseph Juliano, Elizabeth R. Miller, Felicidad Almazan, Joseph L. Witztum, Richard Klemke, Yuri I. Miller. A Zebrafish Model of Hypercholesterolemiainduced vascular inflammation and atherosclerosis. Submitted.

Shi-Jian Ding, Yingchun Wang, Jon M. Jacobs, Wei-Jun Qian, Feng Yang, Aleksey V. Tolmachev, Eric F. Strittmatter, Ronald J. Moore, Matt E. Monroe, Samuel O. Purvine, Quanzhou Luo, Katrina Waters, David G. Camp II, Richard Klemke, Richard D. Smith. Quantitative Phosphoproteome Analysis of Lysophosphatidic Acid Induced Chemotaxis applying Durl-step 180 Labeling coupled wit Immobilized Metal-ion Affinity Chromatography. Journal of Proteome Research.  2008 July 14.  In Press.

Published:

Stoletov, Konstantine, Richard Klemke, Catch of the day, zebrafish as a human cancer model. Oncogene. 2008 27, 4509-4520;doi:101038/onc.2008.95; published online 31 March 2008.

Dwayne G. Stupack, Ainhoa Mielgo, Vicente Torres, Simone Barbero, Konstantin Stoletov, Richard Klemke, William Gerwick, Dennis Carson & Wolf Wrasidlo.  The marine lipopeptide Somocystinamide A triggers apoptosis via caspase 8. PNAS 2008 Feb 19;105(7):2313-8.

Olivier Pertz, Yingchun Wang, Feng Yang , Wei Wang, Laurie J. Gay, Marina A. Gristenko, Therese R. Clauss, David J. Anderson, Tao Liu, Kenneth J. Auberry, David G. Camp II, Richard D. Smith, Richard L. Klemke. Spatial Mapping of the Neurite and Soma Proteomes Reveals A Functional Cdc42/Rac Regulatory Network.  2008 PNAS.  Proc Natl Acad Sci U S A. 2008 Feb 1 [Epub ahead of print] Link to PNAS  

Konstantin Stoletov, Valerie Montal, Robin Lester, Steven Gonias, Richard Klemke. High Resolution Imaging of the Dynamic tumor Cell-Vascular Interface in Transparent Zebrafish. PNAS. 2007. 104(44):17406-11.     Faculty 1000 Score 6.0

Yingchun Wang, Richard L. Klemke*. PhosphoBlast:  A Computational Tool for comparing Phosphoprotein Signatures among Large Datasets. Submitted to Molecular & Cellular Proteomics. 7:145-162.2007.  http://www.f1000biology.com/article/id/1095951

Yingchun Wang, Shi-Jian Ding, Wei Wang, Feng Yang, Jon M. Jacobs, David Camp, II, Richard D. Smith, and Richard L. Klemke.  Methods for Pseudopodia Purification and Proteomic Analysis, Sci. STKE, 2007 (400), p.l4.

Yingchun Wang, Shi-Jian Ding, Wei Wang, Jon M. Jacobs, Wei-Jun Qian, Ronald J. Moore, Feng Yang, David G. Camp II, Richard D. Smith, and Richard L. Klemke. Profiling signaling polarity in chemotactic cells. (Cell Biology)PNAS 2007. 104(20):8328-33. Faculty 1000 Score 6.0 .

Yingchun Wang, and Richard L. Klemke (2007). Biochemical Purification of Pseudopodia from Migratory Cells, Methods in Molecular biology.  A.S. Coutts, ed. (Totowa, NJ: Humana Press Inc.), pp. 55-66.

Wang, Y., Hanley, R. Klemke, R.L. Computational Methods for Comparison of Large Genomic and Proteomic Datasets Reveals Protein Markers of Metastatic Cancer. J Proteome Res. 5(4):907-15. 2006

Pertz, O., Hodgson, L., Klemke, R.L. and Hahn, K.M. Spatio-temporal dynamics of RhoA activity in migrating cells. Nature. 440(7087):1069-72. 2006.

Holcomb, M., Rufini, A., Barilà, D., and Klemke, R.L. Deregulation of Proteasome Function Induces Abl-mediated Cell Death by Uncoupling p130CAS and c-CrkII. J. Biol. Chem. 281(5):2430-40. 2006.

Wozniak M.A., Kwong L., Chodniewicz D., Klemke, R.L. & Keely PJ. R-Ras controls membrane protusion and cell migration through the spatial regulation of Rho and Rac. Mol. Biol. Cell. 16(1):84-96. 2005.

Chodniewicz, D. & Klemke, R.L. Guiding cell migration through directed extension and stabilization of pseudopodia. Exp. Cell Res. 301:31-37. 2004.

Chodniewicz, D. & Klemke, R.L. Regulation of Integrin-mediated Cellular Responses through Assembly of a CAS/Crk Scaffold. Biochimica et Biophysica Acta.

Lin, Y., Park, Z., Lin, D., Brahmbhatt, A., Rio, M. & Klemke, R.L.  Regulation of Cell Migration and Survival by Focal Adhesion Targeting of Lasp-1. J. Cell Biol. 165(3):421-432. 2004.

Emami, S. & Klemke, R.L.(2005) Regulation of Cell Motility by Abl Family Kinases. In T. Koleske (Ed.), Abl Family Kinases in Development and Disease. Landes Bioscience. http://www.eurekah.com/abstract.php?chapid=2426&bookid=185&catid=56.

Smith, M. Leng, J. & Klemke, R.L. Novel design for quantification and purification of neurite outgrowth. BioTechniques. 35:254-256. 2003.

Kain, K., Gooch, S., & Klemke, R.L. Cytoplasmic c-Abl provides a molecular rheostat controlling carcinoma cell survival and invasion. Oncogene. 22(38):6071-6080. 2003.

Brahmbhatt, A. & Klemke, R.L. ERK and RhoA differentially regulate pseudopodia growth and retraction during chemotaxis. J. Biol. Chem. 278:13016-13025. 2003.

Cho, S.Y. & Klemke, R.L  Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. J. Cell. Biol. 156(4):725-736. 2002.

Ting, A.Y., Kain, K.H., Klemke, R.L. & Tsien, R.Y. Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proc. Natl. Acad. Sci. 98(26):15003-15008. 2001.

Kain, K. & Klemke, R.L. Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-Cas complexes. J. Biol. Chem. 276(19):16185-16192. 2001.

Li, E., Stupack, D.G., Brown, S.L., Klemke, R.L., Schlaepfer, D.D. & Nemerow, G.R. Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry. J. Biol. Chem. 275(10):14729-14735. 2000.

Stupack, D.G., Cho, S.Y. & Klemke, R.L. Molecular signaling mechanisms of migration and invasion. Imm. Res. 121:83-88. 2000.

Cho, S.Y. & Klemke, R.L.. Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix. J. Cell. Biol. 149(1):223-236. 2000.

Spencer, K., Graus-Porta, D., Leng, J., Hynes, N. & Klemke, R.L. ErbB-2 is necessary for induction of carcinoma cell invasion by erbB family receptor tyrosine kinases. J. Cell. Biol. 148(4):385-397. 2000.

Leng, J., Klemke, R.L., Reddy, A.C. & Cheresh, D.A. Potentiation of cell migration by adhesion-dependent cooperative signals from the GTPase Rac and Raf kinase. J. Biol. Chem. 274:37855-37861. 1999.

Cheresh, D.A., Leng, J. & Klemke, R.L. Regulation of contraction and membrane ruffling by distinct signals in migratory cells. J. Cell. Biol. 146:1107-1116

Voice, J.K., Klemke, R.L., Le, A. & Jackson, J.H. Four human Ras homologs differ in their abilities to activate Raf-1, induce transformation and stimulate cell motility. J. Biol. Chem. 274:17164-17170. 1999.

Eliceiri, B.P., Klemke, R.L., Stromblad, S. & Cheresh, D.A. Integrin requirement for sustained MAP kinase activity during angiogenesis. J. Cell. Biol. 140(5):1255-1263. 1998.

Klemke, R.L., Leng, J., Molander, R., Brooks, P.C., Vuori, K. & Cheresh, D.A. CAS/Crk coupling serves as a "molecular switch" for induction of cell migration. J. Cell. Biol. 140(4):961-972. 1998

Li, E., Stupack, D., Klemke, R.L, Cheresh, D.A. & Nemerow, G.R. Adenovirus endocytosis and cell motility require distinct signaling pathways mediated by av integrins. J. Virology 7:2055-2061. 1998.

Brooks, P.C., Klemke, R.L., Schon, S., Lewis, J.M., Schwartz, M.A. & Cheresh, D.A. Insulin-like growth factor receptor cooperates with integrin avb5 to promote tumor cell dissemination in vivo. J. Cell. Invest. 99(6):1390-1398. 1997

Klemke, R.L., Cai, S., Giannini, A.L., Gallagher, P.J., de Lanerolle, P. & Cheresh, D.A. Regulation of cell motility by mitogen-activated protein kinase. J. Cell. Biol. 137(2):481-492. 1997.

Brooks, P.C., Stromblad, S., Klemke, R.L., Visscher, D., Sarkar, F.H. & Cheresh, D.A. Anti-integrin avb3 blocks human breast cancer growth and angiogenesis in human skin. J. Clin. Invest. 96:1815-1822. 1995.

Klemke, R.L., Yebra, M., Bayna, E.M. & Cheresh, D.A. Receptor tyrosine kinase signaling required for integrin avb5-directed cell motility but not adhesion on vitronectin. J. Cell. Biol. 127(3):850-866. 1994.

Klemke, R.L. & Weitlauf, H.M. Comparison of the ontogeny of specific cell surface determinants on normal and delayed implanting mouse embryos. J. Repro. Fert. 99:167-172. 1992.

Klemke, R.L. & Rogers, S.H. The effects of THC on macromolecule synthesis in preimplantation mouse embryos. Res. Comm. in Subs. of Abuse. 11(4):207-210. 1990.