1. Wang H, Alarcon CN, Liu B, Watson F, Searles S, Lee CK, Keys J, Pi W, Allen D, Lammerding J, Bui JD, Klemke RL. Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue. Nat Biomed Eng. 2021, Dec 20; doi: 10.1038/s41551-021-00815-9; PMID: 34931007.
  2. Wang H, Lapek J, Fujimura K, Strnadel J, Liu B, Gonzalez DJ, Zhang W, Watson F, Yu V, Liu C, Melo CM, Miller YI, Elliott KC, Cheresh DA, Klemke RL. Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription. Cell Discov. 2018 May 29;4:26. doi: 10.1038/s41421-018-0024-3. eCollection 2018. PubMed PMID: 29872538; PubMed Central PMCID: PMC5972149.
  3. Liu C, Han T, Stachura DL, Wang H, Vaisman BL, Kim J, Klemke RL, Remaley AT, Rana TM, Traver D, Miller YI. Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. Nat Commun. 2018 Apr 3;9(1):1310. doi: 10.1038/s41467-018-03775-y. PubMed PMID: 29615667; PubMed Central PMCID: PMC5882990
  4. Fujimura K, Wang H, Watson F, Klemke RL. KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop. Cancer Res. 2018 Mar 15;78(6):1444-1456. doi: 10.1158/0008-5472.CAN-17-2873. Epub 2018 Jan 10. PubMed PMID: 29321164; PubMed Central PMCID: PMC5856625.
  5. Noriega-Guerra H, Cruz MC, Ribeiro PRL, Strnadel J, Wang H, Klemke RL, Jaeger RG, Freitas VM. ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma. Exp Cell Res. 2018 Feb 15;363(2):271-282. doi: 10.1016/j.yexcr.2018.01.017. Epub 2018 Jan 31. PubMed PMID: 29355494.
  6. Gilder AS, Natali L, Van Dyk DM, Zalfa C, Banki MA, Pizzo DP, Wang H, Klemke RL, Mantuano E, Gonias SL. The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres. Sci Rep. 2018 Feb 14;8(1):2982. doi: 10.1038/s41598-018-21358-1. PubMed PMID: 29445239; PubMed Central PMCID: PMC5813209.
  7. Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, Wright T, Gross E, Peinado C, Park HW, Bui J, Kelber J, Bouvet M, Guan KL, Klemke RL. eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth.Cancer Res. 2017 Apr 15;77(8):1997-2007. doi: 10.1158/0008-5472.CAN-16-2594. Epub 2017 Apr 5. PubMed PMID: 28381547; PubMed Central PMCID: PMC5392372.
  8. Againian, M., Cmpeau, A., Hoover, M., Hou, A., Brabilla, D., Kim, S., Klemke, RL, Kelber, JA. PEAK1 Acts as a Molecular Switch to Regulate Context-DependentTGFβ Responses in Breast Cancer. PLos One 10(8). 2015. PMID: 26267863.
  9. M. Pasillas, S. Shields, R. Reilly, J. Strnadel, C. Behl, R. Park, J. Yates, R. Klemke, S. Gonias, J. Coppinger. Proteomic analysis reveals a role for Bc12-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation. Mol Cell Proteomics. 2015: 14(1):1-14 PMID: 24997994
  10. K. Fujimura, T. Wright, J. Strnadel, S. Kaushai, C. Metildi, A. Lowy, M. Bouvet, J. Kelber, R. Klemke. A Hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer. Cancer Res. 2014; 15;74(22)6671-81. PMID: 25261239.
  11. S. Choi, J. Kelber, X. Jiang, J. Strnadel, K. Fujimura, M. Pasillas, J. Coppinger, R. Klemke. Procedures for the biochemical enrichment and proteomic analysis of the cytoskeletome. Anal Biochem. 2014; 1; 446:102-7, PMID: 24161902 PMCID: PMC 3947189.
  12. B. Spike, J. Kelber, E. Booker, M. Kalathur, R. Rodewald, J. Lipianskaya, J. La, M. He, T. Wright, R. Klemke, G. Wahl, and P. Gray. CRIPTO/GRP778 signaling maintains fetal and adult mammary stem cells ex vivo. Stem Cell Reports. 2014: 2(4): 427-39. PMID: 24749068 PMCID: PMC 3986630.
  13. J. Kelber and R. Klemke. Proteomic and biochemical methods to study the cytoskeletome. Methods Mol. Biol. 2013;1046; 203-18. PMID: 23868590.
  14. K. Stoletov, J. Strnadel, E. Zardouzian, M. Momiyama, F. Park., J. Kelber, D. Pizzo, R. Hoffman, S. Vandenberg, R. Klemke. Role of connexins in metastatic breast cancer and melanoma brain colonization. J. Cell Sci. 2013; 126(Pt4) 904-13. PMID: 23321642 PMCID: PMC3625812.
  15. J. Bristow, T. Reno, M. Jo, S. Gonias, R. Klemke. Dynamic phosphoryation of tyrosine-665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover. J. Biol. Chem. 2013; 288(1)123-31, PMID: 23105102 PMCID: PMC3537006.
  16. J. Kelber, T. Reno, S. Kaushal, C. Metildi, T. Wright, K. Stoletov, J. Weems, F. Park, E. Mose, Y. Wang, R. Hoffman, A. Lowy, M. Bouvet, R. Klemke. KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer. Cancer Res. 2012; 72, 2554-64. PMID: 22589274 PMCID: PMC3366503.
  17. R. Klemke. Trespassing cancer cells: 'fingerprinting' invasive protrusions reveals metastatic culprits. Curr. Opin. Cell Biol. 2012; 24(5) 662-9. PMID: 22980730 PMCID: PMC3489010.
  18. P. Soman, J. Kelber, J. Lee, T. Wright, K. Vecchio, R. Klemke, S. Chen. Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness. Biomaterials. 2012: 3(29):7064-70. PMID: 22809641 PMCID: PMC3420339.
  19. Y. Wang, R. Klemke. Proteomics method for the identification of pseudopodium phosphotyrosine proteins. Methods Mol Biol. 2012; 757:349-65.PMID: 21909922.
  20. J. Kelber, R. Klemke. Book chapter for Cellular Domains. Wiley and Sons. The Actin Cytoskeleton. 2011; Chapter 12, p197-212.
  21. Y. Wang, F. Yang, M. Gritsenko, Y. Wang, T. Clauss, T. Liu, Y. Shen, M. Monroe, D. Lopez-Ferrer, T. Reno, R. Moore, R. Klemke, D. Campbell II, R. Smith.Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells. Proteomics. 2011; 11(10), 2019-26. PMID: 21500348 PMCID: PMC3120047.
  22. Y. Wang, F. Yang, Y. Fu, X. Huang, W. Wang, X. Jiang, M. Gritsenko, R. Zhao, M. Monroe, O. Pertz, S. Purvine, D. Orton, J. Jacobs, D. Camp II, R. Smith, R. Klemke. Spatial phosphoprotein profiling reveals a compartmentalized ERK switch governing neurite growth and retraction. J Biol Chem. 2011; 286(20), 18190-201. PMID: 21454597 PMCID: PMC3093891.
  23. J. Hui, B. Garmy-Susini, C. Avraamides, K. Stoletov, R. Klemke, J. Varner. A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting. Blood. 2010; 116(25):5773-83. PMID: 20826718 PMCID: PMC3031419.
  24. M. Jo, B. Eastman, D. Webb, K. Stoletov, R. Klemke, S. Gonias. Cell Signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. Cancer Res. 2010; 70(21): 8948-58. PMID: 20940399 PMCID: PMC2970644.
  25. J. Kelber, R. Klemke. PEAK1, a novel kinase target in the fight against cancer. Oncotarget. 2010; 1(3): 219-23. PMID: 21301050 PMCID: PMC3057678.
  26. Y. Wang, J. Kelber, H. Tran Cao, G. Cantin, R. Lin, W. Wang, S. Kaushal, J. Bristow, T. Edgington, R. Hoffman, M. Bouvet, J. Yates, III, R. Klemke. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression. Proc Natl Acad Sci USA. 2010; 107(24), 10920-5. PMID: 20534451 PMCID: PMC2890752.
  27. K. Stoletov, H. Kato, E. Zardouzian, J. Kelber, J. Yang, S. Shattil, R. Klemke. Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci. 2010; 123(Pt13), 2332-41. PMID: 20530574 PMCID: PMC2886748.
  28. P. Sampathkumar, S. Ozurt, S. Miller, K. Bain, M. Rutter, T. Gheyi, B. Abrams, Y. Wang, S. Atwell, J. Luz, D. Thompson, S. Wasserman, J. Emtage, E. Park, C. Rongo, Y. Jin, R. Klemke, J. Sauder, S. Burley. Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss of function mutation (Gly1092Glu) of the C. elegans ortholog RPM-1. J Mol Biol. 2010; 397(4): 883-92. PMID: 20156452 PMCID: PMC2881670.
  29. E. Murphy, D. Shields, K. Stoletov, E. Dneprovskaia, M. McElroy, J. Greenberg, J. I.indquist, L. Acevedo, S. Anand, B. Majeti, I. Tsigelny, A. Saldanha, B. Walsh, R. Hoffman, M. Bouvet, R. Klemke, P. Vogt, L. Arnold, W. Wrasidlo, D. Cheresh. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRβ/B-RAF. Proc Natl Acad Sci USA. 2010; 107(9): 4299-304. PMID: 20154271 PMCID: PMC2840076.
  30. C. Green, T. Liu, V. Montel, G. Hsiao, R. Lester, S. Subramaniam, S. Gonias, R. Klemke. Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization. PLoS One. 2009; 4(8), e6713.PMID: 19696929. PMCID: PMC2725301.
  31. K. Stoletov, L. Fang, S. Choi, K. Hartvigsen, L. Hansen, C. Hall, J. Pattison, J. Juliano, E. Miller, F. Almazan, P. Crosier, J. Witztum, R. Klemke, Y. Miller. Vascular Lipid Accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res.2009; 104(8): 952-60. PMID: 19265037 MCID: PMC2834250.
  32. S. Ding, Y. Wang, J. Jacobs, W. Qian, F. Yang, A. Tolmachev, X. Du, W. Wang, R. Moore, M. Monroe, S. Purvine, K. Waters, T. Heibeck, J. Adkins, D. Camp II, R. Klemke, R. Smith. Quantitative phosphoproteome analysis of lysophosphatidic acid induced chemotaxis applying dual-step (18)O labeling coupled with immobilized metal-ion affinity chromatography. J Proteome Res. 2008; 7(10), 4215-24. PMID: 18785766 PMCID: PMC2791456.
  33. K. Stoletov, R. Klemke. Catch of the day, zebrafish as a human cancer model. Oncogene. 2008; 27(33): 4509-20. PMID: 18372910.
  34. W. Wrasidlo, A. Mielgo, V. Torres, S. Barbero, K. Stoletov, R.L. Klemke, W. Gerwick, D. Carson, . G. Stupack. The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci USA. 2008; 105(7):2313-8. PMID: 18268346. PMCID: PMC2268133.
  35. O. Pertz, Y. Wang, F. Yang, W. Wang, L. Gay, M. Gristenko, T. Clauss, D. Anderson, T. Liu, K. Auberry, D. Camp II, R. Smith, R. Klemke. Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network. Proc Natl Acad Sci USA. 2008; 105(6): 1931-6. PMID: 18245386 PMCID: PMC 2542865.
  36. K. Stoletov, V. Montel, R. Lester, S. Gonias, R. Klemke. High resolution imaging of the dynamic tumor cell-vascular interface in transparent zebrafish. Proc Natl Acad Sci USA. 2007; 104(44), 17406-11. PMID: 17954920 PMCID: PMC 2077269.
  37. Y. Wang, R. Klemke. PhosphoBlast, a computational tool for comparing phosphoprotein signatures among large datasets. Mol Cell Proteomics. 2008; 7(1): 145-62. PMID: 17934212.
  38. Y. Wang, S. Ding, W. Wang, F. Yang, J. Jacobs, D. Camp II, R. Smith, R. Klemke. Methods for pseudopodia purification and proteomic analysis. Sci. STKE. 2007; (400): p14. PMID: 17712138.
  39. Y. Wang, S. Ding, W. Wang, J. Jacobs, W. Qian, R. Moore, F. Yang, D. Camp II, R. Smith, R. Klemke. Profiling signaling polarity in chemotactic cells. Proc Natl Acad Sci USA. 2007; 104(20): 8328-33. PMID: 18494752 PMCID: PMC 1895949.
  40. Y. Wang, R. Klemke. Biochemical purification of pseudopodia from migratory cells. Methods Mol Biol. 2007; 370: 55-66. PMID: 17416987.
  41. Y. Wang, R. Hanley, R. Klemke. Computational methods for comparison of large genomic and proteomic datasets reveals protein markers of metastatic cancer. J Proteome Res. 2006; 5(4), 907-15. PMID: 16602698.
  42. O. Pertz, L. Hodgson, R. Klemke, K. Hahn. Spatiotemporal dynamics of RhoA activity in migrating cells. Nature. 2006; 440(7087): 1069-72. PMID: 1654751